This hall contains works created mainly in the first decade of the 16th century. One of the earliest is a Madonna and Child by an unknown artist of the late 15th and early 16th centuries that hangs to the left of the doorway.
The end wall is taken up by a Madonna and Child with Donors (c. 1505) by the major artist Palma Vecchio (Jacopo Negretti, 1480–1528). Another small-sized, but significant work by him, Christ and the Woman Taken in Adultery (1510–11) is on the wall opposite the windows. Next come two early paintings by Titian (Tiziano Vecellio, between 1485 and 1490 – 1576), the future head of the Venetian school: a small Adoration (c. 1508) and a monumental Flight into Egypt (1507–08) featuring the largest landscape in painting at that time. The lyrical intonation in the mood of the countryside is a reminder of the influence exerted on Titian by his teacher, the great Giorgione. Alongside is a Madonna and Child painted by Giorgione (Giorgio da Castelfranco, c. 1477/78–1510) himself, with whom the arrival of the High Renaissance in Venetian art is associated.